INCREDB ID : 317
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Naibedya Chattopadhyay, Ph.D.
Scientist F & Deputy Director 
 
Central Drug Research Institute
Endocrinology Division
Lucknow - 226 001   
Uttar Pradesh   
 
E-mail: n_chattopadhyay@cdri.res.in
Phone: +91-522-2613894
Fax: +91-522-2623405
 
URL: http://cdriindia.org/naibedya.htm
 
Positions Held:
Position Affiliation Time Period
Post Doctoral Fellow Brigham and Womens Hospital, Harvard Medical School, Boston, MA 1994-1998
Instructor Brigham and Womens Hospital, Harvard Medical School, Boston, MA 1998-2003
Assistant Professor Brigham and Womens Hospital, Harvard Medical School, Boston, MA 2003-2006
 
Area of Specialization:
Endocrinology
Research Summary:
Bone anabolic agents
Agents against cancer-induced osteolysis
Anabolic action(s) of calcium-sensing receptor in osteoblasts.
 
Publications:
1. Swarnkar, G., Sharan, K., Siddiqui, J. A., Chakravarti, B., Rawat, P., Kumar, M., Arya, K. R., Maurya, R. and Chattopadhyay, N.  A novel flavonoid isolated from the steam-bark of Ulmus Wallichaiana Planchon stimulates osteoblast function and inhibits osteoclast and adipocyte differentiation. European Journal of Pharmacology. 2011.  [PubMed]
2. Bhargavan, B., Singh, D., Gautam, A. K., Mishra, J. S., Kumar, A., Goel, A., Dixit, M., Pandey, R., Manickavasagam, L., Dwivedi, S. D., Chakravarti, B., Jain, G. K., Ramachandran, R., Maurya, R., Trivedi, A., Chattopadhyay, N. and Sanyal, S.  Medicarpin, a legume phytoalexin, stimulates osteoblast differentiation and promotes peak bone mass achievement in rats: evidence for estrogen receptor beta-mediated osteogenic action of medicarpin. The Journal of Nutritional Biochemistry. 2011.  [PubMed]
3. Siddiqui, J. A., Swarnkar, G., Sharan, K., Chakravarti, B., Gautam, A. K., Rawat, P., Kumar, M., Gupta, V., Manickavasagam, L., Dwivedi, A. K., Maurya, R. and Chattopadhyay, N.  A naturally occurring rare analog of quercetin promotes peak bone mass achievement and exerts anabolic effect on osteoporotic bone. Osteoporosis International : A Journal Established As Result of Cooperation Between the European Foundation For Osteoporosis and the National Osteoporosis. 2011.  [PubMed]
4. Yadav, D. K., Gautam, A. K., Kureel, J., Srivastava, K., Sahai, M., Singh, D., Chattopadhyay, N. and Maurya, R.  Synthetic analogs of daidzein, having more potent osteoblast stimulating effect. Bioorganic & Medicinal Chemistry Letters. 2011.  21, 677-681. [PubMed]
5. Siddiqui, J. A., Sharan, K., Swarnkar, G., Rawat, P., Kumar, M., Manickavasagam, L., Maurya, R., Pierroz, D. and Chattopadhyay, N.  Quercetin-6-C-beta-D-glucopyranoside isolated from Ulmus wallichiana planchon is more potent than quercetin in inhibiting osteoclastogenesis and mitigating ovariectomy-induced bone loss in rats. Menopause. 2011.  18, 198-207. [PubMed]
6. Trivedi, R., Goswami, R. and Chattopadhyay, N.  Investigational anabolic therapies for osteoporosis. Expert Opinion On Investigational Drugs. 2010.  19, 995-1005. [PubMed]
7. Gautam, A. K., Bhargavan, B., Tyagi, A. M., Srivastava, K., Yadav, D. K., Kumar, M., Singh, A., Mishra, J. S., Singh, A. B., Sanyal, S., Maurya, R., Manickavasagam, L., Singh, S. P., Wahajuddin, W., Jain, G. K., Chattopadhyay, N. and Singh, D.  Differential effects of formononetin and cladrin on osteoblast function, peak bone mass achievement and bioavailability in rats. The Journal of Nutritional Biochemistry. 2010.  [PubMed]
8. Tyagi, A. M., Gautam, A. K., Kumar, A., Srivastava, K., Bhargavan, B., Trivedi, R., Saravanan, S., Yadav, D. K., Singh, N., Pollet, C., Brazier, M., Mentaverri, R., Maurya, R., Chattopadhyay, N., Goel, A. and Singh, D.  Medicarpin inhibits osteoclastogenesis and has nonestrogenic bone conserving effect in ovariectomized mice. Molecular and Cellular Endocrinology. 2010.  325, 101-109. [PubMed]
9. Kumar, M., Rawat, P., Dixit, P., Mishra, D., Gautam, A. K., Pandey, R., Singh, D., Chattopadhyay, N. and Maurya, R.  Anti-osteoporotic constituents from Indian medicinal plants. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 2010.  17, 993-999. [PubMed]
10. Pandey, R., Gautam, A. K., Bhargavan, B., Trivedi, R., Swarnkar, G., Nagar, G. K., Yadav, D. K., Kumar, M., Rawat, P., Manickavasagam, L., Kumar, A., Maurya, R., Goel, A., Jain, G. K., Chattopadhyay, N. and Singh, D.  Total extract and standardized fraction from the stem bark of Butea monosperma have osteoprotective action: evidence for the nonestrogenic osteogenic effect of the standardized fraction. Menopause. 2010.  17, 602-610. [PubMed]
11. Sharan, K., Swarnkar, G., Siddiqui, J. A., Kumar, A., Rawat, P., Kumar, M., Nagar, G. K., Manickavasagam, L., Singh, S. P., Mishra, G., Jain, G. K., Maurya, R. and Chattopadhyay, N.  A novel flavonoid, 6-C-beta-d-glucopyranosyl-(2S,3S)-(+)-3',4',5,7-tetrahydroxyflavanone, isolated from Ulmus wallichiana Planchon mitigates ovariectomy-induced osteoporosis in rats. Menopause. 2010.  17, 577-586. [PubMed]
12. Siddiqui, J. A., Swarnkar, G., Sharan, K., Chakravarti, B., Sharma, G., Rawat, P., Kumar, M., Khan, F. M., Pierroz, D., Maurya, R. and Chattopadhyay, N.  8,8''-Biapigeninyl stimulates osteoblast functions and inhibits osteoclast and adipocyte functions: Osteoprotective action of 8,8''-biapigeninyl in ovariectomized mice. Molecular and Cellular Endocrinology. 2010.  323, 256-267. [PubMed]
13. Bandyopadhyay, S., Tfelt-Hansen, J. and Chattopadhyay, N.  Diverse roles of extracellular calcium-sensing receptor in the central nervous system. Journal of Neuroscience Research. 2010.  88, 2073-2082. [PubMed]
14. Trivedi, R., Mithal, A. and Chattopadhyay, N.  Anabolics in osteoporosis: the emerging therapeutic tool. Current Molecular Medicine. 2010.  10, 14-28. [PubMed]
15. Sharan, K., Siddiqui, J. A., Swarnkar, G., Tyagi, A. M., Kumar, A., Rawat, P., Kumar, M., Nagar, G. K., Arya, K. R., Manickavasagam, L., Jain, G. K., Maurya, R. and Chattopadhyay, N.  Extract and fraction from Ulmus wallichiana Planchon promote peak bone achievement and have a nonestrogenic osteoprotective effect. Menopause. 2010.  17, 393-402. [PubMed]
16. Samanta, K., Chakravarti, B., Mishra, J. K., Dwivedi, S. K., Nayak, L. V., Choudhry, P., Bid, H. K., Konwar, R., Chattopadhyay, N. and Panda, G.  Anti-tumor activity of a new series of benzoxazepine derivatives in breast cancer. Bioorganic & Medicinal Chemistry Letters. 2010.  20, 283-287. [PubMed]
17. Bhargavan, B., Gautam, A. K., Singh, D., Kumar, A., Chaurasia, S., Tyagi, A. M., Yadav, D. K., Mishra, J. S., Singh, A. B., Sanyal, S., Goel, A., Maurya, R. and Chattopadhyay, N.  Methoxylated isoflavones, cajanin and isoformononetin, have non-estrogenic bone forming effect via differential mitogen activated protein kinase (MAPK) signaling. Journal of Cellular Biochemistry. 2009.  108, 388-399. [PubMed]
18. Rawat, P., Kumar, M., Sharan, K., Chattopadhyay, N. and Maurya, R.  Ulmosides A and B: flavonoid 6-C-glycosides from Ulmus wallichiana, stimulating osteoblast differentiation assessed by alkaline phosphatase. Bioorganic & Medicinal Chemistry Letters. 2009.  19, 4684-4687. [PubMed]
19. Konwar, R., Chaudhary, P., Kumar, S., Mishra, D., Chattopadhyay, N. and Bid, H. K.  Breast cancer risk associated with polymorphisms of IL-1RN and IL-4 gene in Indian women. Oncology Research. 2009.  17, 367-372. [PubMed]
20. Trivedi, R., Kumar, A., Gupta, V., Kumar, S., Nagar, G. K., Romero, J. R., Dwivedi, A. K. and Chattopadhyay, N.  Effects of Egb 761 on bone mineral density, bone microstructure, and osteoblast function: Possible roles of quercetin and kaempferol. Molecular and Cellular Endocrinology. 2009.  302, 86-91. [PubMed]
21. Sharan, K., Siddiqui, J. A., Swarnkar, G., Maurya, R. and Chattopadhyay, N.  Role of phytochemicals in the prevention of menopausal bone loss: evidence from in vitro and in vivo, human interventional and pharma-cokinetic studies. Current Medicinal Chemistry. 2009.  16, 1138-1157. [PubMed]
22. Liu, Y., Chattopadhyay, N., Qin, S., Szekeres, C., Vasylyeva, T., Mahoney, Z. X., Taglienti, M., Bates, C. M., Chapman, H. A., Miner, J. H. and Kreidberg, J. A.  Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis. Development. 2009.  136, 843-853. [PubMed]
23. Chakravarti, B., Dwivedi, S. K., Mithal, A. and Chattopadhyay, N.  Calcium-sensing receptor in cancer: good cop or bad cop? Endocrine. 2009.  35, 271-284. [PubMed]
24. Singh, U. S., Shankar, R., Kumar, A., Trivedi, R., Chattopadhyay, N., Shakya, N., Palne, S., Gupta, S. and Hajela, K.  Synthesis and biological evaluation of indolyl bisphosphonates as anti-bone resorptive and anti-leishmanial agents. Bioorganic & Medicinal Chemistry. 2008.  16, 8482-8491. [PubMed]
25. Sharan, K., Siddiqui, J. A., Swarnkar, G. and Chattopadhyay, N.  Role of calcium-sensing receptor in bone biology. The Indian Journal of Medical Research. 2008.  127, 274-286. [PubMed]
26. Konwar, R., Gara, R., Singh, M., Singh, V., Chattopadhyay, N. and Bid, H. K.  Association of interleukin-4 and interleukin-1 receptor antagonist gene polymorphisms and risk of benign prostatic hyperplasia. Urology. 2008.  71, 868-872. [PubMed]
27. Chattopadhyay, N., Espinosa-Jeffrey, A., Tfelt-Hansen, J., Yano, S., Bandyopadhyay, S., Brown, E. M. and de, V.  Calcium receptor expression and function in oligodendrocyte commitment and lineage progression: potential impact on reduced myelin basic protein in CaR-null mice. Journal of Neuroscience Research. 2008.  86, 2159-2167. [PubMed]
28. Konwar, R., Chattopadhyay, N. and Bid, H. K.  Genetic polymorphism and pathogenesis of benign prostatic hyperplasia. BJU International. 2008.  102, 536-544. [PubMed]
29. Chattopadhyay, N., Yamaguchi, T. and Brown, E. M.  Ca(2+) receptor from brain to gut: common stimulus, diverse actions. Trends in Endocrinology and Metabolism: TEM. 1998.  9, 354-359. [PubMed]
30. Trivedi, R., Kumar, S., Kumar, A., Siddiqui, J. A., Swarnkar, G., Gupta, V., Kendurker, A., Dwivedi, A. K., Romero, J. R. and Chattopadhyay, N.  Kaempferol has osteogenic effect in ovariectomized adult Sprague-Dawley rats. Molecular and Cellular Endocrinology. 2008.  289, 85-93. [PubMed]
31. Bandyopadhyay, S., Romero, J. R. and Chattopadhyay, N.  Kaempferol and quercetin stimulate granulocyte-macrophage colony-stimulating factor secretion in human prostate cancer cells. Molecular and Cellular Endocrinology. 2008.  287, 57-64. [PubMed]
32. Trivedi, R., Mithal, A. and Chattopadhyay, N.  Recent updates on the calcium-sensing receptor as a drug target. Current Medicinal Chemistry. 2008.  15, 178-186. [PubMed]
33. Sashidhara, K. V., Rosaiah, J. N., Kumar, A., Bid, H. K., Konwar, R. and Chattopadhyay, N.  Cell growth inhibitory action of an unusual labdane diterpene, 13-epi-sclareol in breast and uterine cancers in vitro. Phytotherapy Research : PTR. 2007.  21, 1105-1108. [PubMed]
34. Chattopadhyay, N., Quinn, S. J., Kifor, O., Ye, C. and Brown, E. M.  The calcium-sensing receptor (CaR) is involved in strontium ranelate-induced osteoblast proliferation. Biochemical Pharmacology. 2007.  74, 438-447. [PubMed]
35. Bandyopadhyay, S., Jeong, K. H., Hansen, J. T., Vassilev, P. M., Brown, E. M. and Chattopadhyay, N.  Calcium-sensing receptor stimulates secretion of an interferon-gamma-induced monokine (CXCL10) and monocyte chemoattractant protein-3 in immortalized GnRH neurons. Journal of Neuroscience Research. 2007.  85, 882-895. [PubMed]
36. Mentaverri, R., Yano, S., Chattopadhyay, N., Petit, L., Kifor, O., Kamel, S., Terwilliger, E. F., Brazier, M. and Brown, E. M.  The calcium sensing receptor is directly involved in both osteoclast differentiation and apoptosis. The FASEB Journal : Official Publication of the Federation of American Societies For Experimental Biology. 2006.  20, 2562-2564. [PubMed]
37. Chattopadhyay, N., Jeong, K. H., Yano, S., Huang, S., Pang, J. L., Ren, X., Terwilliger, E., Kaiser, U. B., Vassilev, P. M., Pollak, M. R. and Brown, E. M.  Calcium receptor stimulates chemotaxis and secretion of MCP-1 in GnRH neurons in vitro: potential impact on reduced GnRH neuron population in CaR-null mice. American Journal of Physiology. Endocrinology and Metabolism. 2007.  292, E523-32. [PubMed]
38. Bandyopadhyay, S., Ni, J., Ruggiero, A., Walshe, K., Rogers, M. S., Chattopadhyay, N., Glicksman, M. A. and Rogers, J. T.  A high-throughput drug screen targeted to the 5'untranslated region of Alzheimer amyloid precursor protein mRNA. Journal of Biomolecular Screening : the Official Journal of the Society For Biomolecular Screening. 2006.  11, 469-480. [PubMed]
39. Chattopadhyay, N. and Brown, E. M.  Role of calcium-sensing receptor in mineral ion metabolism and inherited disorders of calcium-sensing. Molecular Genetics and Metabolism. 2006.  89, 189-202. [PubMed]
40. Tfelt-Hansen, J., Kanuparthi, D. and Chattopadhyay, N.  The emerging role of pituitary tumor transforming gene in tumorigenesis. Clinical Medicine & Research. 2006.  4, 130-137. [PubMed]
41. Bandyopadhyay, S., Hartley, D. M., Cahill, C. M., Lahiri, D. K., Chattopadhyay, N. and Rogers, J. T.  Interleukin-1alpha stimulates non-amyloidogenic pathway by alpha-secretase (ADAM-10 and ADAM-17) cleavage of APP in human astrocytic cells involving p38 MAP kinase. Journal of Neuroscience Research. 2006.  84, 106-118. [PubMed]
42. Bandyopadhyay, S., Lion, J. M., Mentaverri, R., Ricupero, D. A., Kamel, S., Romero, J. R. and Chattopadhyay, N.  Attenuation of osteoclastogenesis and osteoclast function by apigenin. Biochemical Pharmacology. 2006.  72, 184-197. [PubMed]
43. Chattopadhyay N.  Effects of calcium-sensing receptor on the secretion of parathyroid hormone-related peptide and its impact on humoral hypercalcemia of malignancy. American Journal of Physiology. Endocrinology and Metabolism. 2006.  290, E761-70. [PubMed]
44. Pang, J. L., Ricupero, D. A., Huang, S., Fatma, N., Singh, D. P., Romero, J. R. and Chattopadhyay, N.  Differential activity of kaempferol and quercetin in attenuating tumor necrosis factor receptor family signaling in bone cells. Biochemical Pharmacology. 2006.  71, 818-826. [PubMed]
45. Tfelt-Hansen, J., Yano, S., John, M., Smajilovic, S., Chattopadhyay, N. and Brown, E. M.  High calcium activates the EGF receptor potentially through the calcium-sensing receptor in Leydig cancer cells. Growth Factors. 2005.  23, 117-123. [PubMed]
46. Brown, E. M., Chattopadhyay, N. and Yano, S.  Calcium-sensing receptors in bone cells. Journal of Musculoskeletal & Neuronal Interactions. 2004.  4, 412-413. [PubMed]
47. Yano, S., Mentaverri, R., Kanuparthi, D., Bandyopadhyay, S., Rivera, A., Brown, E. M. and Chattopadhyay, N.  Functional expression of beta-chemokine receptors in osteoblasts: role of regulated upon activation, normal T cell expressed and secreted (RANTES) in osteoblasts and regulation of its secretion by osteoblasts and osteoclasts. Endocrinology. 2005.  146, 2324-2335. [PubMed]
48. Tfelt-Hansen, J., Ferreira, A., Yano, S., Kanuparthi, D., Romero, J. R., Brown, E. M. and Chattopadhyay, N.  Calcium-sensing receptor activation induces nitric oxide production in H-500 Leydig cancer cells. American Journal of Physiology. Endocrinology and Metabolism. 2005.  288, E1206-13. [PubMed]
49. Yano, S., Macleod, R. J., Chattopadhyay, N., Tfelt-Hansen, J., Kifor, O., Butters, R. R. and Brown, E. M.  Calcium-sensing receptor activation stimulates parathyroid hormone-related protein secretion in prostate cancer cells: role of epidermal growth factor receptor transactivation. Bone. 2004.  35, 664-672. [PubMed]
50. MacLeod, R. J., Yano, S., Chattopadhyay, N. and Brown, E. M.  Extracellular calcium-sensing receptor transactivates the epidermal growth factor receptor by a triple-membrane-spanning signaling mechanism. Biochemical and Biophysical Research Communications. 2004.  320, 455-460. [PubMed]
51. Yano, S., Brown, E. M. and Chattopadhyay, N.  Calcium-sensing receptor in the brain. Cell Calcium. 2004.  35, 257-264. [PubMed]
52. Tfelt-Hansen, J., Yano, S., Bandyopadhyay, S., Carroll, R., Brown, E. M. and Chattopadhyay, N.  Expression of pituitary tumor transforming gene (PTTG) and its binding protein in human astrocytes and astrocytoma cells: function and regulation of PTTG in U87 astrocytoma cells. Endocrinology. 2004.  145, 4222-4231. [PubMed]
53. Chattopadhyay, N., Yano, S., Tfelt-Hansen, J., Rooney, P., Kanuparthi, D., Bandyopadhyay, S., Ren, X., Terwilliger, E. and Brown, E. M.  Mitogenic action of calcium-sensing receptor on rat calvarial osteoblasts. Endocrinology. 2004.  145, 3451-3462. [PubMed]
54. Chattopadhyay, N., T-Felt, H., Godbole, M. M. and Brown, E. M.  Transforming growth factor beta receptor family ligands inhibit hepatocyte growth factor synthesis and secretion from astrocytoma cells. Brain Research. Molecular Brain Research. 2004.  121, 146-150. [PubMed]
55. Ye, C. P., Yano, S., Tfelt-Hansen, J., MacLeod, R. J., Ren, X., Terwilliger, E., Brown, E. M. and Chattopadhyay, N.  Regulation of a Ca2+-activated K+ channel by calcium-sensing receptor involves p38 MAP kinase. Journal of Neuroscience Research. 2004.  75, 491-498. [PubMed]
56. Chattopadhyay, N., Wang, Z., Ashman, L. K., Brady-Kalnay, S. M. and Kreidberg, J. A.  alpha3beta1 integrin-CD151, a component of the cadherin-catenin complex, regulates PTPmu expression and cell-cell adhesion. The Journal of Cell Biology. 2003.  163, 1351-1362. [PubMed]
57. Tfelt-Hansen, J., Chattopadhyay, N., Yano, S., Kanuparthi, D., Rooney, P., Schwarz, P. and Brown, E. M.  Calcium-sensing receptor induces proliferation through p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase but not extracellularly regulated kinase in a model of humoral hypercalcemia of malignancy. Endocrinology. 2004.  145, 1211-1217. [PubMed]
58. Tfelt-Hansen, J., Schwarz, P., Terwilliger, E. F., Brown, E. M. and Chattopadhyay, N.  Calcium-sensing receptor induces messenger ribonucleic acid of human securin, pituitary tumor transforming gene, in rat testicular cancer. Endocrinology. 2003.  144, 5188-5193. [PubMed]
59. Tfelt-Hansen, J., MacLeod, R. J., Chattopadhyay, N., Yano, S., Quinn, S., Ren, X., Terwilliger, E. F., Schwarz, P. and Brown, E. M.  Calcium-sensing receptor stimulates PTHrP release by pathways dependent on PKC, p38 MAPK, JNK, and ERK1/2 in H-500 cells. American Journal of Physiology. Endocrinology and Metabolism. 2003.  285, E329-37. [PubMed]
60. Tfelt-Hansen, J., Schwarz, P., Brown, E. M. and Chattopadhyay, N.  The calcium-sensing receptor in human disease. Frontiers in Bioscience : A Journal and Virtual Library. 2003.  8, s377-90. [PubMed]
61. Chattopadhyay, N., MacLeod, R. J., Tfelt-Hansen, J. and Brown, E. M.  1alpha,25(OH)2-vitamin D3 inhibits HGF synthesis and secretion from MG-63 human osteosarcoma cells. American Journal of Physiology. Endocrinology and Metabolism. 2003.  284, E219-27. [PubMed]
62. MacLeod, R. J., Chattopadhyay, N. and Brown, E. M.  PTHrP stimulated by the calcium-sensing receptor requires MAP kinase activation. American Journal of Physiology. Endocrinology and Metabolism. 2003.  284, E435-42. [PubMed]
63. Chattopadhyay, N., Tfelt-Hansen, J. and Brown, E. M.  PKC, p42/44 MAPK and p38 MAPK regulate hepatocyte growth factor secretion from human astrocytoma cells. Brain Research. Molecular Brain Research. 2002.  102, 73-82. [PubMed]
64. Sanders, J. L., Chattopadhyay, N., Kifor, O., Yamaguchi, T. and Brown, E. M.  Ca(2+)-sensing receptor expression and PTHrP secretion in PC-3 human prostate cancer cells. American Journal of Physiology. Endocrinology and Metabolism. 2001.  281, E1267-74. [PubMed]
65. Chattopadhyay, N. and Brown, E. M.  Retinoic acid receptors are expressed in human primary astrocytes and their agonists inhibit parathyroid hormone-related peptide expression and secretion. Brain Research. Molecular Brain Research. 2001.  92, 172-176. [PubMed]
66. Hjalm, G., MacLeod, R. J., Kifor, O., Chattopadhyay, N. and Brown, E. M.  Filamin-A binds to the carboxyl-terminal tail of the calcium-sensing receptor, an interaction that participates in CaR-mediated activation of mitogen-activated protein kinase. The Journal of Biological Chemistry. 2001.  276, 34880-34887. [PubMed]
67. Chattopadhyay, N., Butters, R. R. and Brown, E. M.  Agonists of the retinoic acid- and retinoid X-receptors inhibit hepatocyte growth factor secretion and expression in U87 human astrocytoma cells. Brain Research. Molecular Brain Research. 2001.  87, 100-108. [PubMed]
68. Yamaguchi, T., Chattopadhyay, N., Kifor, O., Ye, C., Vassilev, P. M., Sanders, J. L. and Brown, E. M.  Expression of extracellular calcium-sensing receptor in human osteoblastic MG-63 cell line. American Journal of Physiology. Cell Physiology. 2001.  280, C382-93. [PubMed]
69. Murphey, E. D., Chattopadhyay, N., Bai, M., Kifor, O., Harper, D., Traber, D. L., Hawkins, H. K., Brown, E. M. and Klein, G. L.  Up-regulation of the parathyroid calcium-sensing receptor after burn injury in sheep: a potential contributory factor to postburn hypocalcemia. Critical Care Medicine. 2000.  28, 3885-3890. [PubMed]
70. Yamaguchi, T., Chattopadhyay, N., Kifor, O., Sanders, J. L. and Brown, E. M.  Activation of p42/44 and p38 mitogen-activated protein kinases by extracellular calcium-sensing receptor agonists induces mitogenic responses in the mouse osteoblastic MC3T3-E1 cell line. Biochemical and Biophysical Research Communications. 2000.  279, 363-368. [PubMed]
71. Sanders, J. L., Chattopadhyay, N., Kifor, O., Yamaguchi, T., Butters, R. R. and Brown, E. M.  Extracellular calcium-sensing receptor expression and its potential role in regulating parathyroid hormone-related peptide secretion in human breast cancer cell lines. Endocrinology. 2000.  141, 4357-4364. [PubMed]
72. Ye, C., Chattopadhyay, N., Brown, E. M. and Vassilev, P. M.  Defective extracellular calcium (Ca(o))-sensing receptor (CaR)-mediated stimulation of a Ca(2+)-activated potassium channel in glioblastoma cells transfected with a dominant negative CaR. Brain Research. Molecular Brain Research. 2000.  80, 177-187. [PubMed]
73. Chattopadhyay, N., Evliyaoglu, C., Heese, O., Carroll, R., Sanders, J., Black, P. and Brown, E. M.  Regulation of secretion of PTHrP by Ca(2+)-sensing receptor in human astrocytes, astrocytomas, and meningiomas. American Journal of Physiology. Cell Physiology. 2000.  279, C691-9. [PubMed]
74. Chattopadhyay N.  Biochemistry, physiology and pathophysiology of the extracellular calcium-sensing receptor. The International Journal of Biochemistry & Cell Biology. 2000.  32, 789-804. [PubMed]
75. Chattopadhyay, N. and Brown, E. M.  Cellular "sensing" of extracellular calcium (Ca(2+)(o)): emerging roles in regulating diverse physiological functions. Cellular Signalling. 2000.  12, 361-366. [PubMed]
76. Ye, C. P., Yamaguchi, T., Chattopadhyay, N., Sanders, J. L., Vassilev, P. M. and Brown, E. M.  Extracellular calcium-sensing-receptor (CaR)-mediated opening of an outward K(+) channel in murine MC3T3-E1 osteoblastic cells: evidence for expression of a functional CaR. Bone. 2000.  27, 21-27. [PubMed]
77. Chattopadhyay, N., Singh, D. P., Heese, O., Godbole, M. M., Sinohara, T., Black, P. M. and Brown, E. M.  Expression of peroxisome proliferator-activated receptors (PPARS) in human astrocytic cells: PPARgamma agonists as inducers of apoptosis. Journal of Neuroscience Research. 2000.  61, 67-74. [PubMed]
78. Yamaguchi, T., Ye, C., Chattopadhyay, N., Sanders, J. L., Vassilev, P. M. and Brown, E. M.  Enhanced expression of extracellular calcium sensing receptor in monocyte-differentiated versus undifferentiated HL-60 cells: potential role in regulation of a nonselective cation channel. Calcified Tissue International. 2000.  66, 375-382. [PubMed]
79. Sanders, J. L., Chattopadhyay, N., Kifor, O., Yamaguchi, T. and Brown, E. M.  Extracellular calcium-sensing receptor (CaR) expression and its potential role in parathyroid hormone-related peptide (PTHrP) secretion in the H-500 rat Leydig cell model of humoral hypercalcemia of malignancy. Biochemical and Biophysical Research Communications. 2000.  269, 427-432. [PubMed]
80. Chattopadhyay, N., Ye, C. P., Yamaguchi, T., Kerner, R., Vassilev, P. M. and Brown, E. M.  Extracellular calcium-sensing receptor induces cellular proliferation and activation of a nonselective cation channel in U373 human astrocytoma cells. Brain Research. 1999.  851, 116-124. [PubMed]
81. Yamaguchi, T., Chattopadhyay, N. and Brown, E. M.  G protein-coupled extracellular Ca2+ (Ca2+o)-sensing receptor (CaR): roles in cell signaling and control of diverse cellular functions. Advances in Pharmacology. 2000.  47, 209-253. [PubMed]
82. Chattopadhyay, N., Ye, C., Yamaguchi, T., Nakai, M., Kifor, O., Vassilev, P. M., Nishimura, R. N. and Brown, E. M.  The extracellular calcium-sensing receptor is expressed in rat microglia and modulates an outward K+ channel. Journal of Neurochemistry. 1999.  72, 1915-1922. [PubMed]
83. Chattopadhyay, N., Ye, C. P., Yamaguchi, T., Vassilev, P. M. and Brown, E. M.  Evidence for extracellular calcium-sensing receptor mediated opening of an outward K+ channel in a human astrocytoma cell line (U87). Glia. 1999.  26, 64-72. [PubMed]
84. Cheng, I., Qureshi, I., Chattopadhyay, N., Qureshi, A., Butters, R. R., Hall, A. E., Cima, R. R., Rogers, K. V., Hebert, S. C., Geibel, J. P., Brown, E. M. and Soybel, D. I.  Expression of an extracellular calcium-sensing receptor in rat stomach. Gastroenterology. 1999.  116, 118-126. [PubMed]
85. Chattopadhyay, N., Ye, C. P., Yamaguchi, T., Kifor, O., Vassilev, P. M., Nishimura, R. and Brown, E. M.  Extracellular calcium-sensing receptor in rat oligodendrocytes: expression and potential role in regulation of cellular proliferation and an outward K+ channel. Glia. 1998.  24, 449-458. [PubMed]
86. Yamaguchi, T., Chattopadhyay, N., Kifor, O., Butters, R. R., Sugimoto, T. and Brown, E. M.  Mouse osteoblastic cell line (MC3T3-E1) expresses extracellular calcium (Ca2+o)-sensing receptor and its agonists stimulate chemotaxis and proliferation of MC3T3-E1 cells. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 1998.  13, 1530-1538. [PubMed]
87. Brown, E. M., Chattopadhyay, N., Vassilev, P. M. and Hebert, S. C.  The calcium-sensing receptor (CaR) permits Ca2+ to function as a versatile extracellular first messenger. Recent Progress in Hormone Research. 1998.  53, 257-337. [PubMed]
88. Yamaguchi, T., Kifor, O., Chattopadhyay, N., Bai, M. and Brown, E. M.  Extracellular calcium (Ca2+o)-sensing receptor in a mouse monocyte-macrophage cell line (J774): potential mediator of the actions of Ca2+o on the function of J774 cells. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 1998.  13, 1390-1397. [PubMed]
89. Lin, K. I., Chattopadhyay, N., Bai, M., Alvarez, R., Dang, C. V., Baraban, J. M., Brown, E. M. and Ratan, R. R.  Elevated extracellular calcium can prevent apoptosis via the calcium-sensing receptor. Biochemical and Biophysical Research Communications. 1998.  249, 325-331. [PubMed]
90. Yamaguchi, T., Chattopadhyay, N., Kifor, O. and Brown, E. M.  Extracellular calcium (Ca2+(o))-sensing receptor in a murine bone marrow-derived stromal cell line (ST2): potential mediator of the actions of Ca2+(o) on the function of ST2 cells. Endocrinology. 1998.  139, 3561-3568. [PubMed]
91. Yamaguchi, T., Olozak, I., Chattopadhyay, N., Butters, R. R., Kifor, O., Scadden, D. T. and Brown, E. M.  Expression of extracellular calcium (Ca2+o)-sensing receptor in human peripheral blood monocytes. Biochemical and Biophysical Research Communications. 1998.  246, 501-506. [PubMed]
92. Riccardi, D., Hall, A. E., Chattopadhyay, N., Xu, J. Z., Brown, E. M. and Hebert, S. C.  Localization of the extracellular Ca2+/polyvalent cation-sensing protein in rat kidney. The American Journal of Physiology. 1998.  274, F611-22. [PubMed]
93. Habib, A. A., Marton, L. S., Allwardt, B., Gulcher, J. R., Mikol, D. D., Hognason, T., Chattopadhyay, N. and Stefansson, K.  Expression of the oligodendrocyte-myelin glycoprotein by neurons in the mouse central nervous system. Journal of Neurochemistry. 1998.  70, 1704-1711. [PubMed]
94. Yamaguchi, T., Kifor, O., Chattopadhyay, N. and Brown, E. M.  Expression of extracellular calcium (Ca2 + o)-sensing receptor in the clonal osteoblast-like cell lines, UMR-106 and SAOS-2. Biochemical and Biophysical Research Communications. 1998.  243, 753-757. [PubMed]
95. Cheng, I., Klingensmith, M. E., Chattopadhyay, N., Kifor, O., Butters, R. R., Soybel, D. I. and Brown, E. M.  Identification and localization of the extracellular calcium-sensing receptor in human breast. The Journal of Clinical Endocrinology and Metabolism. 1998.  83, 703-707. [PubMed]
96. Chattopadhyay, N., Cheng, I., Rogers, K., Riccardi, D., Hall, A., Diaz, R., Hebert, S. C., Soybel, D. I. and Brown, E. M.  Identification and localization of extracellular Ca(2+)-sensing receptor in rat intestine. The American Journal of Physiology. 1998.  274, G122-30. [PubMed]
97. House, M. G., Kohlmeier, L., Chattopadhyay, N., Kifor, O., Yamaguchi, T., Leboff, M. S., Glowacki, J. and Brown, E. M.  Expression of an extracellular calcium-sensing receptor in human and mouse bone marrow cells. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 1997.  12, 1959-1970. [PubMed]
98. Cima, R. R., Cheng, I., Klingensmith, M. E., Chattopadhyay, N., Kifor, O., Hebert, S. C., Brown, E. M. and Soybel, D. I.  Identification and functional assay of an extracellular calcium-sensing receptor in Necturus gastric mucosa. The American Journal of Physiology. 1997.  273, G1051-60. [PubMed]
99. Diaz, R., Hurwitz, S., Chattopadhyay, N., Pines, M., Yang, Y., Kifor, O., Einat, M. S., Butters, R., Hebert, S. C. and Brown, E. M.  Cloning, expression, and tissue localization of the calcium-sensing receptor in chicken (Gallus domesticus). The American Journal of Physiology. 1997.  273, R1008-16. [PubMed]
100. Chattopadhyay, N., Vassilev, P. M. and Brown, E. M.  Calcium-sensing receptor: roles in and beyond systemic calcium homeostasis. Biological Chemistry. 1997.  378, 759-768. [PubMed]
101. Chattopadhyay, N., Legradi, G., Bai, M., Kifor, O., Ye, C., Vassilev, P. M., Brown, E. M. and Lechan, R. M.  Calcium-sensing receptor in the rat hippocampus: a developmental study. Brain Research. Developmental Brain Research. 1997.  100, 13-21. [PubMed]
102. Chattopadhyay, N., Ye, C., Singh, D. P., Kifor, O., Vassilev, P. M., Shinohara, T., Chylack, L. T. and Brown, E. M.  Expression of extracellular calcium-sensing receptor by human lens epithelial cells. Biochemical and Biophysical Research Communications. 1997.  233, 801-805. [PubMed]
103. Butters, R. R., Chattopadhyay, N., Nielsen, P., Smith, C. P., Mithal, A., Kifor, O., Bai, M., Quinn, S., Goldsmith, P., Hurwitz, S., Krapcho, K., Busby, J. and Brown, E. M.  Cloning and characterization of a calcium-sensing receptor from the hypercalcemic New Zealand white rabbit reveals unaltered responsiveness to extracellular calcium. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 1997.  12, 568-579. [PubMed]
104. Chattopadhyay, N., Baum, M., Bai, M., Riccardi, D., Hebert, S. C., Harris, H. W. and Brown, E. M.  Ontogeny of the extracellular calcium-sensing receptor in rat kidney. The American Journal of Physiology. 1996.  271, F736-43. [PubMed]
105. Chattopadhyay, N., Mithal, A. and Brown, E. M.  The calcium-sensing receptor: a window into the physiology and pathophysiology of mineral ion metabolism. Endocrine Reviews. 1996.  17, 289-307. [PubMed]
106. Chattopadhyay, N., Kher, R. and Godbole, M.  Inexpensive SDS/phenol method for RNA extraction from tissues. BioTechniques. 1993.  15, 24-26. [PubMed]
 
Education 
::
M.Sc. Presidency College, Calcutta, India
::
Ph.D. Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Type of Neoplasms
Breast
Female
  Last modified on : Dec 11, 2015
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.