Akhilesh Pandey, M.D., Ph.D.
M.D.,
Armed Forces Medical College, Pune, India,
1988
Intern in Medicine, Kilpauk Medical College,
Madras, India, 1990
Ph.D. in Pathology, University of Michigan, Ann Arbor, MI
1995
Postdoc in Pathology, University of Michigan, Ann Arbor, MI
1996
Resident in Clinical Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA
1998
Postdoc, Whitehead Institute for Biomedical
Research, MIT, Cambridge, MA 2000
Visiting Scientist, University of Southern
Denmark, Odense, Denmark 2001
Research Interests:
Cell surface receptors transmit signals to the interior
of the cell upon binding to a ligand. These signals are
generally transmitted through proteins with catalytic
activity (such as kinases) as well as those without any
catalytic activity (such as adapters). Protein phosphorylation
is a major mechanism of regulating the activity of these
proteins and the formation of multi-protein complexes.
We have cloned a number of signaling molecules that are
involved in signal transduction through receptor tyrosine
kinases (EGF and PDGF receptors), cytokine receptors (IL-3
and TSLP receptor), antigen receptors (T and B cell receptors),
oncogenic kinases (Bcr-Abl) as well as receptor serine-threonine
kinases (TGF-beta and BMP receptors). Using a combination
of molecular biology and proteomics-based approaches including
mass spectrometry, our laboratory aims to dissect these
signaling pathways further and to elucidate the mechanisms
of cross-talk between them. We are developing methods
to identify novel proteins involved in these signal transduction
pathways in a global fashion using mass spectrometry based
high-throughput methods. We are also interested in genomic
analyses using bioinformatics to catalog all proteins
and their modular domain structures and interaction partners
Areas of Current Research:
Awards and Honors:
Experimental Pathologist-in-training Award, American
Society for Investigative Pathology, 1996
Howard Temin Award, National Cancer Institute, 1997
Kimmel Scholar Award, Sidney Kimmel Foundation for Cancer Research, 2003
Beckman Young Investigator Award, Arnold and Mabel Beckman Foundation, 2004