Pancreatic Cancer Database

ADAM metallopeptidase domain 17

Gene Symbol

ADAM17

Chromosome Locus

2p25

Alternate Names

A disintegrin and metalloproteinase domain 17; Tumor necrosis factor alpha converting enzyme; TACE

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
PDEC	RT-PCR	Increased		Ringel et al. 2006
CAPAN-1	RT-PCR	Increased		Ringel et al. 2006
CAPAN-2 BxPC-3	RT-PCR	Increased		Ringel et al. 2006
PANC-1	RT-PCR	Increased		Ringel et al. 2006
HPAF/CD18	RT-PCR	Increased		Ringel et al. 2006
T3N4	RT-PCR	Increased		Ringel et al. 2006
QGP1	RT-PCR	Increased		Ringel et al. 2006
SW979	RT-PCR	Increased		Ringel et al. 2006
Colo357	RT-PCR	Increased		Ringel et al. 2006

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Kahlert et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Ringel et al.
PanIN-3	Immunohistochemistry	Increased		Ringel et al.

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
CAPAN-1	FACS	Increased		Ringel et al. 2006
PANC-1	FACS	Increased		Ringel et al. 2006
BxPC-3	FACS	Increased		Ringel et al. 2006
PDEC	FACS	Increased		Ringel et al. 2006
CAPAN-1	Western blot	Increased		Ringel et al. 2006
CAPAN-2	Western blot	Increased		Ringel et al. 2006
BxPC-3	Western blot	Increased		Ringel et al. 2006
HPAF/CD18	Western blot	Increased		Ringel et al. 2006
PANC-1	Western blot	Increased		Ringel et al. 2006
T3N4	Western blot	Increased		Ringel et al. 2006
QGP1	Western blot	Increased		Ringel et al. 2006
SW979	Western blot	Increased		Ringel et al. 2006

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
RNA	RT-PCR	Increased		Ringel et al. 2006

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

-

Secreted

-

Body Fluid

-

External Links

HPRD	Entrez Gene	OMIM	HGNC
04703	6868	603639	HGNC:195

Pancreatic Cancer Database was funded by the "Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins."