ADAM metallopeptidase domain 8
Gene Symbol   ADAM8 Chromosome Locus   10q26.3
 
  Alternate Names    
     
 
A disintegrin and metalloproteinase domain 8; Human leukocyte differentiation antigen; Cell surface antigen MS2
 
   
 
  RNA Alterations     
     
 
Cancer Type
Experiment Type
Expression Level
Fold Change
PubMed ID
Invasive ductal adenocarcinoma DNA microarray
Increased
5
Nakamura et al. 2004
Invasive ductal adenocarcinoma DNA microarray
Increased
4
Logsdon et al. 2003
Invasive ductal adenocarcinoma RT-PCR
Increased
5.3
Valkovskaya et al. 2007
Cell Line
Experiment Type
Expression Level
Fold Change
PubMed ID
BxPC-3 DNA microarray
Increased
5
 Logsdon et al. 2003
MIA PaCa-2 DNA microarray
Increased
5
 Logsdon et al. 2003
CFPAC-1 DNA microarray
Increased
5
 Logsdon et al. 2003
HPAC DNA microarray
Increased
5
 Logsdon et al. 2003
MPanc-96 DNA microarray
Increased
5
 Logsdon et al. 2003
SU.86.86 DNA microarray
Increased
5
 Logsdon et al. 2003
SW1990 DNA microarray
Increased
5
 Logsdon et al. 2003
 
   
 
  Protein Alterations     
     
 
Cancer Type
Experiment Type
Expression Level
Fold Change
PubMed ID
Invasive ductal adenocarcinoma Immunohistochemistry
Increased
Valkovskaya et al.
Invasive ductal adenocarcinoma Western blot
Increased
Valkovskaya et al.
Cell Line
Experiment Type
Expression Level
Fold Change
PubMed ID
No Data
 
   
 
 Chronic Pancreatitis    
     
 
RNA/Protein
Experiment Type
Expression Level
Fold Change
PubMed ID
RNA RT-PCR
Increased
2.4
 Binkley et al.
Protein Immunohistochemistry
Increased
Valkovskaya et al.
Protein Western blot
Increased
Valkovskaya et al.
 
   
 
 
  Expressed in Body Fluid /Plasma Membrane  
     
 
     
 
Plasma Membrane -
Secreted - 
Body Fluid
-
 
   
 
   
 
  External Links     
     
 
HPRD
Entrez Gene
OMIM
HGNC
 
   
 
 
 
 

Pancreatic Cancer Database was funded by the "Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins."