Institute of Bioinformatics

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Kannan Rangiah, Ph.D.
Faculty Scientist

Institute of Bioinformatics
Discoverer Building, International Tech Park, Whitefield
Bangalore - 560 066
E-mail: rangiah at ibioinformatics dot org
Phone: +91-98-86601365 Fax: +91-80-28416132

Education

	Ph.D. in Chemistry, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India
	M.Sc. in Chemistry, Bharathidasan University, Trichy, Tamil Nadu, India
	B.Sc. in Chemistry, Sri Ramakrishna Mission Vidyalaya, P.N.Palayam, Coimbatore, Tamil Nadu, India

Positions Held

	Postdoc, University of Pennsylvania (UPENN), Philadelphia, United States, 2006 to 2011.
	Facility Incharge, Metabolomics Facility, Centre for Cellular and Molecular Platforms (C-CAMP), Bangalore, India, 2011 to 2017.
	Scientist Fellow, Food Safety and Analytical Quality Control laboratory (FS&AQCL), Central Food Technological Research Institute (CFTRI), Mysore, India, 2017 to 2020.

Area of Specialization

	Bio-analytical Chemistry
	Organic chemistry
	Proteomics
	Metabolomics

Projects Involved

	Completed a NIH funded project “Maternal Malnutrition and Lactation Performance in India” by developing LC-MS methods to quantify both micro (water and fat soluble vitamins) & macronutrients (total protein and lactose) from human milk and sera.
	As a Co-PI involved in a project entitled “Generation of induced pluripotent stem cell (iPSC) models of conotruncal heart defects (CTDs) to investigate the disease-relevant molecular mechanisms using advanced proteomics and metabolomics approaches” (technically approved-SERB).
	As a Co-PI involved in a project entitled “Proteomics and biochemical analysis for identification of novel bio markers for predicting pregnancy induced hypertension (PIH): In a health and demographic cohort from Dibrugarh” (technically approved-ICMR).

Research Areas

	Developing disease specific markers by “metabotyping” individuals, using advanced Liquid Chromatography-Mass Spectrometry (LC-MS) based metabolomics
	Validation of disease specific protein markers by using targeted quantitative proteomics approach from clinical samples
	Developing LC-MS/MS based methods for newborn screening (NBS) and Inborn errors of metabolism (IEM) screening
	Developing LC-MS based methods to quantify micro- and macro-nutrients to assess the diseased conditions

Membership

	Lifetime member of Proteomics Society of India

Publications
Research papers: 27; Book Chapters: 3; Written articles: 2
Choudary, B. M., Sreenivasa Chowdari, N., Lakshmi Kantam, M., and Kannan, R. (1999). Fe (III) Exchanged Montmorillonite: A Mild and Eco-friendly Catalyst for Sulfonylation of Aromatics. Tetrahedron Letters 40, 2859 –2862. [Article]
Kannan, R., Sahal, D., and Chauhan, V. S. (2002). Heme-Artemisinin Adducts Are Crucial Mediators of the Ability of Artemisinin to Inhibit Heme Polymerization. Chemistry & Biology. 9, 321-332. [PubMed]
Sahal, D., Kannan, R., Shina, A., Babbarwal, V., Prakash, B. G., Singh, G., and Chauhan, V. S. (2002). Specific and instantaneous one-step chemodetection of histidine-rich proteins by Pauly’s stain. Analytical Biochemistry. 308, 405-408. [PubMed]
Sahal, D., Kannan, R. , and Chauhan, V.S. (2003). Applying malaria parasite’s heme detoxification system for screening potential antimalarial drugs. Analytical Biochemistry. 312, 258-260. [PubMed]
Kannan, R., Kumar, K., Sahal, D., Kukreti, S. and Chauhan, V. S. (2005). Reaction of Artemisinin with Hemoglobin: Implications for antimalarial activity. Biochemical Journal. 385, 409-418. [PubMed]
Hwa, L. S, Rangiah, K., Williams, M. V., Wehr, A. Y., DuBois, R. N., Blair, I. A. (2007). Cyclooxygenase-2-mediated metabolism of arachidonic acid to 15-oxo-eicosatetraenoic acid by rat intestinal epithelial cells. Chem Res Toxicol. 20(11):1665-75. [PubMed]
Rangiah, K., Tippornwong, M., Sangar, V., Austin, D., Tétreault, M. P., Rustgi§, A. K., Blair, I. A., Yu, K. H.(2009). Biomarker Discovery in Colon Cancer Using a Differential Secreted Proteome Approach. Journal of Proteome Research. 8, 5153–5164. [PubMed]
Rangiah, K., Hwang, W. T., Mesaros, C., Vachani, A. and Blair, I. A. (2011). Nicotine exposure and metabolizer phenotypes from ana lysis of urinary nicotine and its 15 metabolites by LC–MS. Bioanalysis. 3(7), 745–761. [PubMed]
Rangiah, K., Shah, S. J., Vachani, A., Ciccimaro, E., Blair, I. A. (2011). Liquid chromatography/mass spectrometry of pre-ionized Girard P derivatives for quantifying estrone and its metabolites in serum from postmenopausal women. Rapid Commun Mass Spectrom. 15;25(9):1297-307. [PubMed]
Rangiah, K. and Palakodeti, D. (2013). Comprehensive analysis of neurotransmitters from regenerating planarian extract using an ultrahigh-performance liquid chromatography /mass spectrometry/selected reaction monitoring method. Rapid Commun. Mass Spectrom. 27, 2439–2452. [PubMed]
Rangiah, K.(2014). Sensitive UHPLC-MS/SRM method for quantifying olanzapine metabolites and degradation products from sera. Anal. Methods. 6, 5250. [Article]
Wang, Q., Rangiah, K., Mesaros, C., Snyder, N. W., Song, H., Vachini, A., Blair, I. A.(2015). Ultrasensitive quantification of serum estrogens in postmenopausal women and older men by liquid chromatography-tandem mass spectrometry. Steroids. 96, 140-152. [PubMed]
Natarajan, N., Ramakrishnan, P., Lakshmanan, V., Palakodeti, D.,Rangiah, K.(2015). A Quantitative Metabolomics Peek into Planarian Regeneration Analyst. 140, 3445–3464 [PubMed]
Kuravadi, N. A., Yenagi, V., Rangiah, K., Mahesh, H. B., Rajamani, A., Shirke, M. D., Russiachand, H., Loganathan, R. M., Lingu, C. S., Siddappa, S., Ramamurthy, A., Sathyanarayana, B. N. and Gowda, M. (2015). Comprehensive analyses of genomes, transcriptomes and metabolites of neem Tree. PeerJ. 3:e1066 [PubMed]
Wang, Q., Zhang, S., Guo, L., Busch, C. M., Jian, W., Weng, N., Snyder, N. W., Rangiah, K., Mesaros, C. and Blair, I. A. (2015). Serum apolipoprotein A-1 quantification by LC-MS with a SILAC internal standard reveals reduced levels in smokers. Bioanalysis. 22, 2895-2911 [PubMed]
Rangiah, K., Varalaxmi, B. A. and Gowda, M. (2016). UHPLC-MS/SRM Method for Quantification of Neem Metabolites from Leaf Extracts of Meliaceae Family Plants Anal. Methods. 8, 2020-2031 [Article]
Ramakrishnan, P., Nair, S. and Rangiah, K. (2016). A Method for Comparative Metabolomics in Urine Using High Resolution Mass Spectrometry. Journal of Chromatography A. 1443, 83–92 [PubMed]
Ramakrishnan, P. and Rangiah, K. (2016). UHPLC-MS/SRM Method for Analysis of Phenolics from Fresh Camellia sinensis Leaves from Nilgiri Hills. Manuscript accepted in Analytical Methods. 8, 8033–8041 [Article]
Tejavathi, D. H., Sujatha, B. S. and Rangiah, K. (2017). Estimation of Curcuminoids in Curcuma Karnatakensis (White Turmeric) - an Endemic Taxon. Asian J Pharm Clin Res. 8, 8033–8041 [Article]
Polachi, N., Subramaniyan, B., Nagaraja, P., Rangiah, K., Ganeshan, M. (2018). Extract from Butea monosperma inhibits beta-catenin/Tcf signaling in SW480 human colon cancer cells. Gene Reports. 10, 79-89 [Article]
Sarkar, A., Mukundan, N., Sowndarya, S., Dubey, V. K., Babu, R., Lakshmanan, V., Rangiah, K., Panicker, M. M., Palakodeti, D., Subramanian, S. P., Ramaswamy, S. (2019). Serotonin is essential for eye regeneration in planaria Schmidtea mediterranea FEBS Letters. 593, 3198-3209 [PubMed]
Shetty, S. A., Young, M. F., Taneja, S.,Rangiah, K. (2020). Quantification of B-vitamins from different fresh milk samples using ultra-high performance liquid chromatography mass spectrometry/selected reaction monitoring methods. J Chrom A. 1609, 460452. [PubMed]
Shetty, S. A., Young, M. F., Taneja, S. Rangiah, K. (2020) Effect of fat on protein estimation in milk and its correlation with lactose in different milk types: a small-scale study. Asisan Journal of Dairy and Food Research. 39, 278-285. [Article]
Shetty, S. A., Rangiah, K. (2020). Simple click chemistry-based derivatization to quantify endogenous formaldehyde in milk using ultra-high-performance liquid chromatography tandem mass spectrometry in selected reaction monitoring mode. Rapid Commun Mass Spectrom. 34, e8865. [Article]
Mehta, R., Shetty, S. A., Young, M., Ryan, P. B., Rangiah, K. (2021). Quantification of aflatoxin and ochratoxin contamination in animal milk using UHPLC-MS/SRM method: a small-scale study. Journal of Food Science Technology. J Food Sci Technol. 58, 3453–3464. [Article]
Mehta, R., Wenndt, A. J., Girard, A. W., Taneja, S., Ranjan, S., Ramakrishnan, U., Martorell, R., Ryan, P. B., Rangiah, K., Young, M. F. (2021). Mycotoxin exposure in breastmilk and food systems from India: A cross-sectional study. Matern Child Nutr. 17:e13100. [PubMed]
Chandran, J., Bellad, A., Ramarajan, M. G., Rangiah, K. (2021) Applications of quantitative metabolomics to revolutionize early diagnosis of inborn errors of metabolism in India. Review article submitted to Analytical Science Advances. [Article]
Rangiah, K. and Palakodeti, D. Quantification of Neurotransmitters from Intact and Regenerating Planarians Using UHPLC-MS/SRM Method. Book Chapter in Methods in Molecular Biology, Humana Press.
Rangiah, K. and Gowda, M. Method to quantify plant secondary metabolites: Quantification of neem metabolites from leaf, bark and seed extracts as an example. Book Chapter in ‘The Neem Genome’, Springer Nature Switzerland.
Agasimundin, V. B., Rangiah, K., Sheetal, A. and Gowda, M. Neem Microbiome. Book Chapter Book Chapter in ‘The Neem Genome’, Springer Nature Switzerland.
Rangiah, K. (2015). Metabolomics and its future applications. Cutting Edge. 7-11.
Chandran, J., Bellad, A., Ramarajan, M. G., Rangiah, K. (2022). Inborn Errors of Metabolism-Importance of Screening in Newborns. Cutting Edge. 9-13.
Patent
Sahal, D., Kannan, R., and Chauhan, V. S. Method for screening a candidate substance as a potential drug for the treatment of malaria. Indian Patent Application No: 705/DEL/2002, filed 1st July 2002.