Institute of Bioinformatics - Dr. Sanjib Chaudhary

Ph.D. in Biotechnology, Institute of Life Sciences (iBRIC-ILS), Bhubaneswar, Odisha, India

M.Sc. in Molecular Biology and Biotechnology, Tezpur University, Tezpur, Assam, India

Faculty Scientist, Institute of Bioinformatics, India, February 2025 - Present

Assistant Professor (Ramalingaswami Fellow), Jyoti and Bhupat Mehta School of Health Science and Technology, IIT Guwahati, Assam, India, April 2024 - January 2025

Junior Faculty, Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States, November 2020 - February 2024

Post-doctoral Research Associate, Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States, Nov 2016 - October 2020

Appadurai, M. I., Chaudhary, S., Shah, A., Natarajan, G., Alsafwani, Z. W., Khan, P., Shinde, D. D., Lele, S., Smith, L., Nasser, M. W., Batra, S. K.*, Ganti, A. K.*, Lakshmanan, I.* (2025). ST6GalNAc-I mediates tumor cell sialylation through NECTIN2/MUC5AC and its impact on immunosuppression and angiogenesis in non-small cell lung cancer. Journal of Clinical Investigation . In press.

Appadurai, M. I., Alsafwani, Z. W., Chaudhary, S., Shah, A., Somavarapu, P., Dooshety, S. N., Kubicek, B. S., Batra, S. K., Lakshmanan, I., Ganti, A. K. (2025). Ixazomib Overcomes Platinum Resistance and Induces Autophagy-Mediated Cell Death in Lung Adenocarcinoma. Journal of Thoracic Oncology. 20(4):S9 [Article]

Shah, A., Salam, S., Chaudhary, S., Muthamil, I. A., Lakshmanan, I., Batra, S. K., Ganti, A. K. (2025). Targeting MUC16-Mediated KRASi Resistance in NSCLC. . Journal of Thoracic Oncology. 20(4):S4-S5 [Article]

Chaudhary, S., Siddiqui, J. A., Pothuraju, R.*, Bhatia, R.* (2025). Ribosome Biogenesis, Altered Metabolism and Ribotoxic Stress Response in Pancreatic Ductal Adenocarcinoma. Cancer Letters. 612:217484 [Article]

Maurya, S. K., Gautam, S. K.#, Jaramillo-Gomez, J. A.#, Rehman, A.#, Zaidi, M. A. A., Khan, P., Fatima, M., Khan, M. A., Anwar, L., Alsafwani, Z. W., Kanchan, R. K., Pothuraju, R., Vengoji, R., Venkata, R. C., Natarajan, G., Bhatia, R., Atri, P., Perumal, N. K., Chaudhary, S., Mohiuddin, S., Lakshmanan, I., Mahapatra, S., Talmon, G., Smith, L., Santamaria-Barri, J. A., Ganti, A. K., Siddiqui, J. A., Cittelly, D. M., Batra, S. K., Nasser, M. W. (2025). Mucin5AC promotes breast cancer brain metastasis through cMET/CD44v6. Clinical Cancer Research. 31(5):921-935 [Article]

Chaudhary, S., Siddiqui, J., Appadurai, M. I., Maurya, S., Nasser, M. W., Blowers, E., Swanson, B. J., Batra, S. K., Lakshmanan, I., Ganti, A. K. (2024). Dissecting the MUC5AC/ANXA2 Signaling Axis: Implications for Brain Metastasis in Lung Adenocarcinoma.. Experimental Molecular Medicine. 56(6):1450-1460 [Article]

Kumar, M. A., Basit, A., Masoodi, T., Chaudhary, S., Assad, A., Bhat, M. R., Shah, Z. A., Akil, A. A. S., Bhat, A. A., Batra, S. K. and Macha, M. A. (2024). Nuclear receptor subfamily 4A2: Novel Role and a potential therapeutic lead in cancers. Journal of Clinical Oncology. 42(16_suppl):e18017-e18017 [Article]

Shah, A., Chaudhary, S., Lakshmanan, I., Aithal, A., Marimuthu, S., Gautam, S., Rauth, S., Kshirsagar, P., Cox, J., Natarajan, G., Bhatia, R., Mallya, K., Rachagani, S., Nasser, M., Ganti, A. K., Jain, M., Ponnusamy, M., Batra, S. K. (2023). A novel chimeric antibody directed towards cell-surface tethered Mucin 16 dampens pancreatic and lung cancer progression. . NPJ Precision Oncology. 7(1):74 [Article]

Chaudhary, S., Maurya, S., Nallasamy, P., Marimuthu, S., Shah, A., Chirravuri-Venkata, R., Lele, S., Seshacharyulu, P., Ponnusamy, M., Nasser, W., Batra, S. K., Lakshmanan, I. (2023). MUC16 promotes TripleNegative Breast Cancer Lung Metastasis by Modulating RNA-Binding Protein ELAVL1/HUR. . Breast Cancer Research. 25(1) [Article]

Khan, P., Siddiqui, J. A., Kshirsagar, P. G., Chirravuri-Venkata, R., Maurya, S. K., Mirzapoiazova, T., Perumal, N., Chaudhary, S., Kanchan, R., Fatima, M., Khan, M. A., Rehman, A. U., Lakshmanan, I., Mahapatra, S., Talmon, G. A., Kulkarni, P., Ganti, A. K., Jain, M., Salgia, R., Batra, S. K., Nasser, M. W. (2023). MicroRNA-1 attenuates the growth and metastasis of small cell lung cancer through CXCR4/FOXM1/RRM2 axis.. Molecular Cancer. 22(1) [Article]

Chaudhary, S., Maurya, S. K., Siddiqui, J., Nasser, M. W., Batra, S. K., Lakshmanan, I., Ganti, A. K. (2023). MUC5AC promotes brain metastases and colonization in non-small cell lung cancer.. Cancer Research. 83(7_Supplement):1283-1283 [Article]

Lakshmanan, I.*, Marimuthu, S.*, Chaudhary, S., Seshacharyulu, S., Rachagani, S., Muniyan, S., Chirravuri-Venkata, R., Atri, P., Rauth, S., Nimmakayala, R., Siddiqui, J., Shailendra, G., Shah, A., Natarajan, G., Parte, S. C., Bhyravbhatla, N., Mallya, K., Haridas, D., Talmon, G., Smith, L., Kumar, S., Ganti, A. K., Jain, M., Ponnusamy, M. P., Batra, S. K. (2022). Muc16 Depletion Diminishes KRAS-induced Tumorigenesis and Metastasis by Altering Tumor Microenvironment factors in Pancreatic Ductal Adenocarcinoma.. Oncogene. 41(48):5147-5159 [Article]

Pothuraju, R., Pai, P., Chaudhary, S., Siddiqui, J. A., Cox, J. L., Kaur, S., Rachagani, S., Roy, H. K., Bouvet, M., Batra, S. K. (2022). Depletion of transmembrane mucin 4 (Muc4) alters intestinal homeostasis in a genetically engineered mouse model of colorectal cancer. Aging (Albany NY).. 14(5):2025-2046 [Article]

Seshacharyulu, P., Halder, S., Nimmakayala, R., Rachagani, S., Chaudhary, S., Atri, P., ChirravuriVenkata, R., Ouellette, M. M., Carmicheal, J., Gautam, S. K., Vengoji, R., Wang, S., Li, S., Smith, L., Talmon, G. A., Klute, K., Ly, Q., Reames, B. N., Grem, J. L., Berim, L., Padussis, J. C., Kaur, S., Kumar, S., Ponnusamy, M. P., Jain, M., Lin, C., Batra, S. K. (2022). Disruption of FDPS/Rac1 axis radiosensitizes pancreatic ductal adenocarcinoma by attenuating DNA damage response and immunosuppressive signalling.. EbioMedicine.. 75 [Article]

Siddiqui, J. A., Seshacharyulu, P., Muniyan, S., Pothuraju, R., Khan, P., Vengoji, R., Chaudhary, S., Maurya, S. K., Lele, S. M., Jain, M., Datta, K., Nasser, M. W., Batra, S. K. (2022). GDF15 promotes prostate cancer bone metastasis and colonization through osteoblastic CCL2 and RANKL activation.. Bone Research. 10(1):06-Jan [Article]

Chaudhary, S., Shah, A., Pothuraju, R., Lakshmanan, I., Ganti, A. K., Batra, S. K. (2022). Cancer Metabolism and Aggressive Tumor Behavior. Immuno-Oncology Crosstalk and Metabolism. Springer Nature. 1:21-43 [Article]

Maurya, S. K., Siddiqui, J. A., Gautam, S. K., Kanchan, R., Pothuraju, R., Natarajan, G., Atri, P., Venkata, R. C., Bhatia, R., Khan, P., Rehman, A., Chaudhary, S., Perumal, N., Mahapatra, S., Chand, H. S., Jain, M., Santamaria-Barriab, J. A., Cittelly, D. A., Batra, S. K., Nasser, M. W. (2022). A novel role of MUC5AC/CD44v6/c-Met axis in breast cancer brain metastasis.. Cancer Research. 82(12_Supplement):2431-2431 [Article]

Khan, P., Siddiqui, J. A., Maurya, S. K., Mirzapoiazova, T., Kanchan, R., Chirravuri Venkata, R., Atri, P., Tang, W., Perumal, N. K., Kshirsagar, P., Fatima, M., Khan, M., Chaudhary, S., Rehman, A., Lakshmanan, I., Mahapatra, S., Kulkarni, P., Ganti, A. K., Jain, M., Oupicky, D., Salgia, R., Batra, S. K., Nasser, M. W. (2022). MicroRNA1 targets CXCR4/FOXM1/RRM2 axis regulating small cell lung cancer growth and metastasis. . Cancer Research. 82(12_Supplement):1489 [Article]

Pothuraju, R., Chaudhary, S., Rachagani, S., Kaur, S., Roy, H. K., Bouvet, M., Batra, S. K. (2021). "Mucins, gutmicrobiota, and postbiotics role in colorectal cancer.". Gut Microbes. 13(1):1974795 [Article]

Chaudhary, S., Pothuraju, R., Rachagani, S., Siddiqui, J. A., Siddiqui, J. A., Atri, P., Mallya, K., Nasser, M. N., Sayed, Z., Lyden, E. R., Smith, L., Gupta, S. D., Ralhan, R., Jones, D. T., Ganti, A. K., Macha, M. A., Surinder, K. Batra. (2021). Dual blockade of EGFR and CDK4/6 delays head and neck squamous cell carcinoma progression by inducing metabolic rewiring. Cancer Letters. 510:79-92 [Article]

Lakshmanan, I., Chaudhary, S., Vengoji, R., Seshacharyulu, P., Rachagani, S., Carmicheal, J., Jahan, R., Atri, P., Chirravuri-Venkata, R., Gupta, R., Marimuthu, S., Perumal, N., Rauth, S., Kaur, S., Mallya, K., Smith, L. M., Lele, S. M., Ponnusamy, M. P., Nasser, M. W., Salgia, R., Batra, S. K., Ganti, A. K. (2021). ST6GalNAc-I promotes lung cancer metastasis by altering MUC5AC sialylation.. Molecular Oncology. 15(7):1866-1881 [Article]

Lakshmanan, I., Chaudhary, S., Perumal, N. K., Batra, S. K., Ganti, A. K. (2021). IGF-1R Inhibition in Small Cell Lung Cancer: Role of Brigatinib.. Journal of Thoracic Oncology. 16(3):S221 [Article]

Chaudhary, S., Dam, V., Ganguly, K., Sharma, S., Atri, P., Chirravuri, R., Cox, J. L., Sayed, Z., Jones, D. T., Ghersi, D.*, Macha, M. A.*, Batra, S. K.* (2020). Differential mutation spectrum and immune landscape in African Americans versus Whites: A possible determinant to health disparity in head and neck cancer. Cancer Letters. 492:44-53 [Article]

Pothuraju, R., Rachagani, S., Krishn, S. R.*, Chaudhary, S.*, Nimmakayala, R. K., Siddiqui, J. A., Ganguly, K., Lakshmanan, I., Cox, J. L., Mallya, K., Kaur, S., Batra, S. K. (2020). Molecular implications of MUC5AC-CD44 axis in colorectal cancer progression and chemoresistance.. Molecular Cancer. 19(1):37 [Article]

"Pothuraju, R., Krishn, S. R., Gautam, S. K., Pai, P., Ganguly, K., Chaudhary, S., Rachagani, S., Kaur, S., Batra, S. K." (2020). Mechanistic and Functional Shades of Mucins and Associated Glycans in Colon Cancer. Cancers (Basel). 12(3):649 [Article]

Venkata, R. C., Ghersi, D., Ganti, A. K., Lakshmanan, I., Chaudhary, S., Batra, S. K., Nasser, M. W. (2020). 1q21. 3 amplification modulates therapy sensitivity in Triple-Negative Breast Cancer.. bioRxiv. [Article]

Macha, M. A., Rachagani, S., Chaudhary, S., Sayed, Z., Jones, D. T., Batra, S. K. (2020). Receptor Tyrosine Kinase Signaling Pathways as a Goldmine for Targeted Therapy in Head and Neck Cancers.. Gene Regulation and Therapeutics for Cancer. 1 ed. (CRC Press) . [Article]

Chaudhary, S., Pothuraju, R., Sayed, Z., Jones, D. T., Batra, S. K., Macha, M. A. (2020). Deregulation of NOTCH 1/NR4A2 signaling axis in head and neck cancer pathogenesis. . Clinical Cancer Research. 26(12_Supplement_2):A31-A31 [Article]

Chaudhary, S., Ganguly, K., Muniyan, S., Pothuraju, R., Sayed, Z., Jones, D. T., Batra, S. K., Macha, M. A. (2019). Immunometabolic alterations by HPV infection: New Dimension to Head and Neck Cancer Disparity.. J Natl Cancer Inst.. 111(3):233-244 [Article]

Pothuraju, R., Rachagani, S., Junker, W. M., Chaudhary, S., Saraswathi, V., Kaur, S., Batra, S. K. (2018). Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting.. J Exp Clin Cancer Res.. 37(1):319 [Article]

Qazi, A. K., Siddiqui, J. A., Jahan, R., Chaudhary, S., Walker, L. A., Sayed, Z., Jones, D. T., Batra, S. K., Macha, M. A. (2018). Emerging therapeutic potential of graviola and its constituents in cancers.. Carcinogenesis. 39(4):522-53 [Article]

Chaudhary, S., Pothuraju, R., Atri, P., Rachagani, S., Batra, S. K., Macha, M. A. (2020). NR4A2 role in head and neck cancer: Mechanistic and functional analysis. Cancer Research. 78(13_Supplement):1909-1909 [Article]

Krishna, B. M., Chaudhary, S., Mishra, D. R., Naik, S. K., Suklabaidya, S., Adhya, A. K., Mishra, S. K. (2018). Estrogen Dependent Regulation of Estrogen Related Receptor ? and its role in Cell Cycle in Breast Cancer.. BMC Cancer. 18(1):607 [Article]

Krishna, B. M., Chaudhary, S., Panda, A. K., Mishra, D. R., Mishra, S. K. (2018). An updated meta- analysis on Her2 Ile655Val polymorphism and its association with breast cancer risk: a case-control study.. Scientific Reports. 8(1):7427 [Article]

Kumari, K., Das, B., Adhya, A., Chaudhary, S., Senapati, S., Mishra, S. K. (2018). Nicotine associated breast cancer in smokers is mediated through high level of EZH2 expression which can be reversed by methyltransferase inhibitor DZNepA.. Cell Death & Disease. 9(2):152 [Article]

Chaudhary, S., Krishna, B. M., Mishra, S. K. (2017). A novel FOXA1/ESR1 interacting pathway: A study of OncomineÖ breast cancer microarrays.. Oncology Letters. 14(2):1247-1264 [Article]

Chaudhary, S., Madhukrishna, B., Adhya, A. K., Keshari, S., Mishra, S. K. (2016). Overexpression of caspase 7 is ER? dependent to affect proliferation and cell growth in breast cancer cells by targeting p21(Cip).. Oncogenesis. 5(4):e219 [Article]

Mishra, D. R., Chaudhary, S., Krishna, B. M., Mishra, S. K. (2015). Identification of Critical Elements for Regulation of Inorganic Pyrophosphatase (PPA1) in MCF7 Breast Cancer cells.. PLoS One. 10(4):e0124864 [Article]

Chaudhary, S., Panda, A. K., Mishra, D. R., Mishra, S. K. (2013). Association of +331G/A PgR polymorphism with susceptibility to female reproductive cancer: evidence from a meta- analysis.. PLoS One. 8(1):e53308 [Article]

Sar, P., Bhargava, D. K., Sengupta, D., Rath, B., Chaudhary, S., Mishra, S. K. (2012). In Human Breast Cancer Cells TR? Competes with ER? for Altering BCl2/Bax Ratio through SMP30- Mediated p53 Induction.. J Cancer Sci Ther . 4(8):227-234 [Article]

Bhargava, D. K., Sengupta, D., Chaudhary, S., Peter, R., Mishra, D. R., Mishra, S. K.* (2012). ERR? regulates transcriptional activity of ER? as well as ER? by modulating BCAS2 expression and leads to FST- mediated induction of nuclear fragmentation in ER-positive MCF-7 breast carcinoma cells.. Cancer Research. 72(8_Supplement):LB-27 [Article]

Mishra, S. K.*, Sar, P., Rath, B., Bhargava, D., Sengupta, D., Chaudhary, S. (2012). In Human breast cancer cells thyroid hormone signaling overshadows estrogen signaling on SMP30 gene leading to induction of apoptosis.. Cancer Research. 72(8_Supplement):4961-4961 [Article]

Received Ramalingaswami Re-Entry fellowship, Department of Biotechnology (DBT), Govt. of India (2022-2023)

Outstanding Rising Star, Dept. of Biochemistry and Molecular Biology, University of Nebraska Medical Center (UNMC), Omaha, Nebraska, United States (2023)

Outstanding Performance Scholarship, Dept. of Biochemistry and Molecular Biology, UNMC, Omaha, Nebraska, United States (2017)

Best Oral Presentation, National Student Research Convention, India (2016)

International Travel Support from DBT to attend EACR Conference, Amsterdam, Netherlands (2013)

Best Research Presentation, Institute of Life Sciences, Bhubaneswar, Odisha, India (2012)

DBT fellowship for pursuing PhD program (2008-2013)

GATE Qualified, Indian Institute of Technology (2007)

DBT studentship for pursuing Master's program (2006-2008)